Figure 2: Genomic rearrangements in BRCA2-mutant prostate cancer.
From: Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
(a) Survey of genome-wide somatic genomic rearrangements (GRs) in BRCA2-mutant tumour PCa from seven patients. CTX—inter-chromosomal translocation; DEL—deletion; INV—inversion. Multiple foci from the same patient are indicated in the same patient covariate colour, where sample type colour indicates microdissected invasive carcinoma (IC) in blue and intraductal carcinoma of the prostate (IDC) in yellow. Top bar plots show the frequency of specimens in BRCA2-mutant PCa (bottom) and sporadic PCa from men 50 years of age or younger (middle) or sporadic PCa from men older than 50 years of age (top). Scatterplot at top indicates FDR-corrected P values of a two-sided proportion test comparing frequency of GRs observed in BRCA2-mutant versus sporadic PCa. (b) A circos plot showing the proportions of BRCA2-mutant (blue) and sporadic PCa (red) with breakpoints in each mega-basepair bin. Bins with significantly different proportions between BRCA2-mutant and sporadic PCa (FDR-correct proportions test) are highlighted in yellow, and have the number of BRCA2-mutant samples indicated. Only chromosomes with at least one differentially recurrent GR are shown.
