Figure 4: Cl− conductance is dependent on intracellular release of Ca2+.
From: Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons
(a–c) Sample traces of whole-cell current in VNO neurons from WT (a), TRPC2−/− (b) and WT with CsMSF internal solution (c) in response to first urine application (U), urine with 2 μM ruthenium red (RR), second urine application after washout (U), urine with 50 μM thapsigargin (TG) and third urine application after washout (U). (d) Relative response for each application in WT (n=9; grey squares), TRPC2−/− (n=7; white circles) and WT with CsMSF internal solution (n=6; black triangles). *P<0.05 and **P<0.01 for comparison with controls (pairwise t-test). All pairs marked with * have post hoc analysis of variance test, P<0.01.
