Figure 8: FA metabolism and early activation of CD4+ T cells. | Nature Communications

Figure 8: FA metabolism and early activation of CD4+ T cells.

From: Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

Figure 8

Top panel: antigenic stimulation induces both fatty acid biosynthesis and fatty acid uptake programmes in CD4+ T cells. Both fatty acid biosynthesis and fatty acid uptake programmes are required for robust proliferation after antigenic stimulation. Inhibition of either fatty acid biosynthesis or fatty acid uptake programmes results in insufficient proliferation after antigenic stimulation. Activate CD4+ T cells do not survive and undergo apoptosis when both fatty acid biosynthesis and fatty acid uptake programmes are dampen. Bottom panel: TCR/CD28-mTORC1 signalling axis controls fatty acid uptake and biosynthesis programmes through the induction of PPARγ and the activation of SREBP1 in activated CD4+ T cells, respectively. PPARγ and SREBP1 directly bind to target genes and regulate their expression. GW9662: a selective, irreversible antagonist of PPARγ, TOFA: an allosteric inhibitor of ACC1.

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