Figure 4: Restoration of ATM point mutation renders cells resistant to MEK inhibition.
From: MEK inhibitors block growth of lung tumours with mutations in ataxia–telangiectasia mutated
(a) Schematic outline of CRISPR/Cas9 rescue experiment in ATM mutant NCI-H23 cells. (b) Sanger sequence chromatogram of cells treated as in a. Red dashed box indicates the mutant cytosine (C) that is replaced by adenosine (A).
