Figure 7: TRIM31 deficiency ameliorates DSS-induced colitis. | Nature Communications

Figure 7: TRIM31 deficiency ameliorates DSS-induced colitis.

From: The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

Figure 7

Mice were given 3% DSS in their drinking water for 5 days, followed by regular drinking water. (a) Body weight, (b) stool consistency and (c) rectal bleeding score were scored daily. (d–h) Mice were killed on day 6. Macroscopic appearances (d) and colon lengths (e) of the mice were measured. Histopathological changes in colon tissue were examined by H&E staining (f) Scale bars, 50μm. Immunoblot analysis of lysates from colon tissue (g,h). *P<0.05, **P<0.01, ***P<0.001 (one-way analysis of variance, ANOVA).

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