Figure 3: SK channels conduct mAHP currents but do not affect spike-frequency adaptation in TC neurons. | Nature Communications

Figure 3: SK channels conduct mAHP currents but do not affect spike-frequency adaptation in TC neurons.

From: The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Figure 3

(a) A 200 pA depolarizing current was injected for 1 s to induce tonic firing in a TC neuron in apamin-free buffer followed by apamin-containing buffer. (b) AHP potentials after current injection were averaged in both apamin-free and apamin-containing buffer (n=6 from three mice; **P=0.0054, paired t-test). A substantial decrease in post-injection AHP was observed when apamin was applied. (c) The number of spikes during current injection was increased by apamin treatment (n=6 from three mice; **P=0.0096, paired t-test). (d) No change in the adaptation index was observed (n=6 from three mice), indicating that SK channels do not significantly contribute to spike adaptation in TC neurons (P=0.25, paired t-test). Error bars represent mean±s.e.

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