Figure 8: In vivo active targeting contribution. | Nature Communications

Figure 8: In vivo active targeting contribution.

From: Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

Figure 8

(a) Epf images of mice bearing MCF-7 xenografts and (b) isolated tumours, acquired 5 or 48 h after exposure to 5NP-1Tz, 5NP-1IgG, 5NP-2Tz or 5NP-2IgG, labelled with AF660. The minima and maxima of the logarithmic colour scales are in (p s−1 cm−2 sr−1) (μW cm−2)−1 (from left to right): (a) 5 h: 3.46 × 107–6.06·107; 3.46 × 107–6.06 × 107; 5.79 × 107–7.04 × 107; and 5.79 × 107–7.04·107; (a) 48 h: 7.91 × 107–1.00 × 108; 3.46 × 107–6.06 × 107; 8.43 × 107–1.11 × 108; and 8.43 × 107–1.11 × 108; (b) 5NP-1Tz and 5NP-1IgG: 1.85 × 106–8.23 × 106; (b) 5NP-2Tz and 5NP-2IgG: 3.79 × 106–1.43 × 107.

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