Table 1 ARMC5-binding proteins identified by Y2H assay.
From: Armc5 deletion causes developmental defects and compromises T-cell immune responses
Gene name | PBC score | Binding clones | Different clones | Major known function |
|---|---|---|---|---|
DAPK1 | A | 13 | 4 | Tumour suppressor, apoptosis, autophagy |
ARMC5 | B | 2 | 2 | Self-dimerization |
STK24 | B | 3 | 3 | Apoptosis, upstream of MAPK, acts on Tao |
TTF1 | B | 3 | 2 | Transcription terminator, apoptosis, tumour risk |
POLR2A | B | 3 | 2 | DNA-directed RNA polymerase II subunit RPB1 |
CUL3 | C | 2 | 2 | E3 component, WNK degradation, BTB domain, cell cycle, cyclin E degradation |
CDCA7L | D | 1 | 1 | Cell cycle, transcription co-activator, c-Myc interactor, FoxP3-binding |
C10orf46 (CACUL1) | D | 1 | 1 | CDK2-associated, cell cycle, promotes proliferation |
E2F2 | D | 1 | 1 | Cell cycle, transcription factor, T-cell quiescence |
FAM65B | D | 1 | 1 | Skeletal muscle development, hearing |
FLJ20105 (PICH) | D | 1 | 1 | cell division |
HUWE1 | D | 6 | 1 | Ubiquitination and proteasomal degradation, Base-excision repair, neural differentiation and proliferation |
KIF11 | D | 1 | 1 | ATP-dependent microtubule motor activity |
PCBP1 | D | 2 | 1 | Cadherin binding, involved in cell-cell adhesion, Burkitt lymphoma |
RPN2 | D | 1 | 1 | Endopeptidase activity, ubiquitin-dependent protein catabolic process |
TCF12 | D | 1 | 1 | Immune response, regulation of transcription |
ZBTB40 | D | 2 | 1 | Bone mineralization, cellular response to DNA damage stimulus |
