Figure 5: Frequencies of persistent antibody clonotypes among BM plasma cells are temporally stable.
From: Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire
(a) Circos plot of shared CDR-H3 antibody clonotypes between adjacent time points across 6.5 years for Donor 1 (top). Circos plot of the persistent clonotypes across all time points (bottom). Each band in the outermost perimeter represents the clonotypes found in a given time point, sorted by decreasing frequency. The inner curved lines indicate the same clonotype shared by two time points. Green indicates high frequency; purple, low frequency; with lighter colours indicating intermediate frequency. (b) Gene usage frequency over time of the 23 persistent clonotypes (see Methods) found in all time points. Plots are sorted by decreasing mean frequency. Gene names (for IGHV and IGHJ), representative amino acid sequences and isotype are above each plot. (The 165 persistent CDR-H3 antibody clonotypes for Donor 2 are shown in Supplementary Fig. 12.)
