Figure 2: Multinucleation induced by p120 loss occurs independent of cadherin association. | Nature Communications

Figure 2: Multinucleation induced by p120 loss occurs independent of cadherin association.

From: p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

Figure 2

(a) Quantification of bi- and multinucleation in control and dox-treated E-cadherin-deficient mILC-1 p120-iKD cells over three consecutive passages of dox-treated in the presence of dox. Statistical significance was determined using the χ2-test. *P<0.05/‡P<0.05 (binucleation and multinucleation respectively). (b) IF of p120 and E-cadherin in dox-treated U2OS p120-iKD cells reconstituted with FL p120-1A or p120-1A K401M. Right panels show magnifications of representative areas denoted by the dotted squares. Scale bar, 10 μm. (c) Quantification of bi- and multinucleation in dox-treated U2OS p120-iKD reconstituted with empty vector (control), p120-1A FL or p120-1A K401M. Statistical significance was determined using the Student’s t-test. Shown are data from three independent experiments. Results are expressed as mean±s.d. *P<0.05/‡P<0.05 (binucleation and multinucleation, respectively).

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