Figure 4: miR-182 silencing impairs TGFβ-induced EMT and invasion. | Nature Communications

Figure 4: miR-182 silencing impairs TGFβ-induced EMT and invasion.

From: MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

Figure 4

(a) Protein expression of EMT markers and SMAD7 in EpRas and MCF10AT cells after TGFβ stimulation and miR-182 inhibition. (b) Immunofluorescence analyses of EMT makers in EpRas and MCF10AT. (c) Morphological changes of EpRas and MCF10AT cells. (d) Migration of EpRas and MCF10AT cells (n=4). (e) Transwell invasion of SCP28 and NCI-H1299 cells (n=4). Scale bars, 50 μm. *P<0.05, **P<0.01, ***P<0.001 by student’s t-test. Error bars are defined as s.d.

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