Figure 3: Surface conservation comparison of cohesin HEAT repeat subunits.

The Scc2, SA2^Scc3 (PDB I.D. 4PK7) and Pds5 (PDB I.D. 5F0O) structures all exhibit a hook-like curve built with strong conservation at their respective neck regions. All three structures can be presented as three regions: neck, cleftand base. (a) Surface conservation of Scc2 hook showing invariant (ruby) to less conserved (cyan) surfaces. (b) Surface conservation of SA2^Scc3 in the SA2^Scc3–Scc1 complex showing invariant (ruby) to less conserved (cyan) SA2^Scc3 surfaces. (c) Surface conservation of Pds5 in the Pds5–Scc1 complex showing invariant (ruby) to less conserved (cyan) Pds5 surfaces.