Figure 1: CB2R selectivity of cannabinoid reference ligands on mouse and human CBRs. | Nature Communications

Figure 1: CB2R selectivity of cannabinoid reference ligands on mouse and human CBRs.

From: Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity

Figure 1

CB2R selectivity for all cannabinoid receptor reference ligands are presented as the difference in mean pKi values between CB2R and CB1R for both the human (black bars) and mouse (white bars) orthologues. From left to right: ligands with decreasing CB2R selectivity (from HU308 to Gp-1a), nonselective ligands (from HU210 to CP55940), ligands with CB1R selectivity (AM251 and SR141716A). pKi values are obtained from three independent experiments performed in duplicate. Error bars shown in the figure represent the s.e. of the mean.

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