Figure 5: Summary of off-target activity.
From: Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Summary of the total amount of off-targets per reference ligand. CP55940 is the most nonselective one with 17 off-targets, whereas JWH133 seems to be the most selective of the available agonists. Of the antagonists, SR144528 seems to be the most selective ligand. Off-target activity in the CEREP panel, on serine hydrolases, or on AEA reuptake inhibition is defined as >50% difference in effect compared to basal levels at a concentration of 10 μM and/or a submicromolar potency on the given off-target.
