Figure 6: Hypothetical working model of Linc-RAM functions.
From: Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD
Linc-RAM is transcriptionally upregulated by MyoD and directly binds to MyoD in muscle cells. In differentiating cells, Linc-RAM facilitates the recruitment of the SWI/SNF core to myogenic gene promoters through interaction with MyoD, thereby promoting chromatin remodelling and assembly of the transcriptome for transcriptional initiation of myogenic differentiation genes.
