Figure 7: Synthesis of cassettes A and B. | Nature Communications

Figure 7: Synthesis of cassettes A and B.

From: [Au]/[Ag]-catalysed expedient synthesis of branched heneicosafuranosyl arabinogalactan motif of Mycobacterium tuberculosis cell wall

Figure 7

Reagents and conditions: (a) AuCl3 (7 mol%), CH2Cl2, 4 Å MS powder, 25 °C, 2 h, 81% for 25 and 50% for 28. (b) Py·HF, THF:Py (5:1), 0 °C→25 °C, 4 h, 80% for 26 and 75% for 28. (c) AuCl3 (7 mol%), AgOTf (7 mol%), CH2Cl2, 4 Å MS powder, 25 °C, 2 h, 48% for 29 and 45% for 27. (d) Br2, CH2Cl2, 4 Å MS powder, 10 min, 0 °C followed by propargyl alcohol, 2,6-lutidine, tetrabutylammonium iodide, 0 °C→25 °C, 12 h, 88% for 2 and 86% for 4.

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