Figure 2: Crystal structure of the catalytic CtMC1core complex bound to nucleotide-free CtYpt7–N125I. | Nature Communications

Figure 2: Crystal structure of the catalytic CtMC1core complex bound to nucleotide-free CtYpt7–N125I.

From: Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1

Figure 2

(a) The content of the asymmetric unit is shown, comprising two copies of Ypt7 and two Mon1–Ccz1 heterodimers that interact via the domain-swapped helix α3 of Mon1. (b) Stereo image of the 2FO–FC electron density map at 1.8σ contour level of the switch I, switch II and P-loop region of CtYpt7–N125I bound to MC1. (c) Complex structures of MC1 with Ypt7 where the domains’ swap was corrected to represent the likely functional unit. (d) Complex structure of TRAPP with Ypt1. The different interaction interfaces between GTPase and GEF are marked.

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