Figure 3: GDF10 is a crucial modulator of rachis topology. | Nature Communications

Figure 3: GDF10 is a crucial modulator of rachis topology.

From: Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme

Figure 3

(a) Compared with the RCAS-GFP (control) infected neonatal primary remiges, GDF10 and BMP2 mis-expressing feathers developed enlarged rachises as shown by Hematoxylin & Eosin (H&E) staining and KRT75 in situ hybridization. Nuclear pSMAD1/5/8 positive cells also increased in the rachis region. Dotted red lines highlight the rachis. Scale bar, 100 μm. (b) RCAS-β-Catenin infected neonatal remiges developed expanded rachis without notable upregulation of GDF10 expression. Dotted red lines highlight the rachis. (c) RCAS-GDF10 infection increased nuclear β-Catenin positive cells in the pulp adjacent to the rachis. Scale bar, 100 μm.

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