Figure 2: An intact blood–brain barrier in Glut1 DS model mice. | Nature Communications

Figure 2: An intact blood–brain barrier in Glut1 DS model mice.

From: Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein

Figure 2

Evaluation of (a) CSF:Serum IgG and albumin ratios and (b) CSF index fails to provide evidence of any extravasation of serum proteins into the CSF of adult Glut1 DS mutant mice. P>0.05, t-test, N≥4 mice of each genotype. (c) Labelled IgG systemically administered into Glut1 DS mutants does not escape into the neuropil. Note green fluorescence outside the microvasculature following chemically induced disruption of the BBB.

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