Figure 7: Brain capillary network restored following early but not late repletion of the Glut1 protein. | Nature Communications

Figure 7: Brain capillary network restored following early but not late repletion of the Glut1 protein.

From: Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein

Figure 7

(a) Representative immuno-histochemical photomicrographs of the thalamic microvasculature in relevant controls and mutants treated with AAV9-Glut1 at various stages of the disease. Note persistent fragmentation and reduced complexity of the capillary network in vehicle-treated mutants and mutants treated at 8 weeks of age, an intermediate capillary density in cohorts treated at 2 weeks of age and a relatively normal microvasculature in mice administered virus at PND3. Quantitative estimation of (b) aggregate cerebral capillary length, (c) mean vessel length and (d) number of branches per capillary in the different cohorts of mice. ***, P<0.001, one-way ANOVA, n≥9 regions from N≥3 mice in each cohort examined.

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