Figure 10: Ameliorated renal dysfunction and injury in fructokinase knockout mice undergoing CIN.
From: Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
(a) Serum glucose levels in control and streptozocin injected wild type (WT) and fructokinase-deficient (KHK-A/C KO) mice at 2 weeks post injection. (b) Serum creatinine, (c) urinary NGAL and (d) histology/ periodic acid-Schiff staining. Scale bar: 100 μm. (d) Renal cortical sorbitol and (e) renal cortical fructose levels in 2-week diabetic animals receiving either vehicle (V) or contrast (Ct) for 24 h. n=5–9 animals per group. Data indicate mean±s.e.m. **P<0.01 versus baseline or within the same group. ##P<0.01. Statistical analysis was performed with ANOVA with ad hoc analysis by Bonferroni's method to compare all columns. Green arrows denote tubules with significant dilatation.
