Figure 7: Reduced renal inflammation in fructokinase knockout mice undergoing iAKI.
From: Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
(a) Representative western blot demonstrating nuclear and cytosolic expression of the NF-κB subunit p65 and their regulator IkBa (uncropped blots are presented as shown in Supplementary Fig. 2). (b) Time-course analysis of mRNA levels of the proinflammatory cytokine il-6 and the chemokine ccl2 in wild type (WT) and fructokinase-deficient (KHK-A/C KO) mice undergoing iAKI. Data indicate mean±s.e.m. ***P<0.001 between WT and KHK-A/C KO. n=5–9 animals per group with two different studies. Statistical analysis was performed with ANOVA with ad hoc analysis by Bonferroni's method to compare all columns.
