Figure 9: Improved renal dysfunction in luteolin-receiving mice after ischaemic insult.
From: Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
(a) Urinary fructose—normalized to creatinine—levels in wild type (WT) and fructokinase-deficient (KHK-A/C KO) mice at 24 h post sham operation or ischaemic acute kidney injury (iAKI). (b) Dose–response effect of vehicle (V) or luteolin (Lut) in 24 h urinary fructose production in mice undergoing iAKI. (c) Representative periodic acid-Schiff-stained images of the same groups as in (b) (below indicate average±s.d. of serum creatinine obtained for each group). Data indicate mean±s.e.m. **P<0.01 and ***P<0.001 versus baseline or within the same group. #P<0.05. Statistical analysis was performed with ANOVA with ad hoc analysis by Bonferroni's method to compare all columns. Green colour denotes statistical difference versus sham. Red colour denotes statistical difference versus vehicle. n=3 animals per dose. Scale bar: 100 μm.
