Figure 8: Model of CRP–microvesicle interaction.
From: Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
pCRP (yellow) binds to the plasma membrane of activated monocytes. It is subsequently released on membrane-derived microvesicles (blue). Microvesicle-associated pCRP is converted to pCRP* (red). pCRP* can activate the complement system by binding C1q (light green) or dissociate into individual mCRP subunits.
