Table 1 In vitro neutralization of influenza B viruses by 46B8.

From: A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

Influenza B Strain

Lineage

IC 50 (nM)

95% CI (nM)

B/Phuket/3073/2013

Yamagata

0.73

0.65–0.82

B/Massachusetts/2/2012

Yamagata

0.69

0.61–0.78

B/Wisconsin/1/2010

Yamagata

0.64

0.53–0.76

B/Bangladesh/3333/2007

Yamagata

0.75

0.62–0.92

B/Victoria/504/2000

Yamagata

0.67

0.62–0.73

B/Brisbane/60/2008

Victoria

0.86

0.72–1.04

B/Malaysia/2506/2004

Victoria

0.58

0.36–0.91

B/Russia/1/1969

Ancestral

0.73

0.61–0.86

B/Massachusetts/3/1966

Ancestral

0.80

0.65–0.98

B/Maryland/1/1959

Ancestral

0.95

0.71–1.26

B/Lee/10/1940

Ancestral

0.68

0.55–0.85

  1. CI, confidence interval; IC50, half-maximal inhibitory concentration.
  2. neutralization was tested in a plaque reduction assay.