Figure 1: Flow chart highlighting the approach and samples used to detect SNPs associated with PSA from GWAS. | Nature Communications

Figure 1: Flow chart highlighting the approach and samples used to detect SNPs associated with PSA from GWAS.

From: Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Figure 1

First we undertook an unconditional discovery GWAS in the KP non-Hispanic white non-cases. Thirty-eight SNPs associated with PSA (P<5 × 10−7) were then included as covariates in a second conditional discovery GWAS. All SNPs associated with PSA (P<5 × 10−7) from these two GWAS (38+23) were evaluated for replication in two steps, first in an analysis of the replication cohorts alone, and then in a meta-analysis combining the discovery and replication cohorts. A total of 40 independent SNPs (27 in unconditional GWAS, 13 in conditional GWAS) met criteria of combined meta P<5 × 10−8, replication meta P<0.1, and same effect direction in discovery/replication.

Back to article page