Figure 2: Results from a GWAS of PSA levels in 28,503 Kaiser Permanente non-Hispanic white non-cases.

P values are for variant associations with log-transformed PSA levels, adjusted for age and ancestry principal components using a linear regression model. Black and grey peaks indicate novel findings. Dark purple and magenta indicates previously reported PSA level associated genotyped and imputed hits, respectively, and light purple and magenta indicate those within 0.5 Mb of previously reported hits that were replicated at genome-wide significance. Dark pink and red points denote previously reported PCa SNPs genotyped and imputed, respectively, and pink and orange indicate those within 0.5 Mb of previously reported PCa SNPs genotyped and imputed. Dark blue and green points denote the previously reported genotyped and imputed, respectively, SNPs associated with PSA levels only (and not PCa), and light blue and green those within 0.5 Mb previously reported hits. Circles denoted genotyped SNPs and triangles represent imputed SNPs.