Figure 3: Comparison of the effect of SNPs on PSA levels versus on prostate cancer (PCa) in KP non-Hispanic whites.

Results are from separate models regressing PSA level (linear regression) or PCa (logistic regression, unadjusted for PSA levels are small circles, adjusted for PSA levels are large circles) on each of the 40 PSA level SNPs from Tables 2 and 3 and the 105 previously identified PCa SNPs. (a) Effect sizes. (b) P values. Red points are associated with PSA levels only (from Tables 2 and 3), blue with PCa only (P<0.00125, a Bonferroni correction for 40 SNPs), purple with both PSA and PCa (for small circles, this also includes previously identified PCa associated SNPs), and black are previously identified PCa associated SNPs (not significant here). Previously reported PCa SNPs within 0.5Mb of a PSA SNP were removed: rs1775148, rs6763931, rs2242652, rs10486567, rs2928679, rs1512268, rs12543663, rs10086908, rs1016343, rs13252298, rs6983561, rs116041037, rs445114, rs16902104, rs6983267, rs7000448, rs11986220, rs10993994, rs2252004, rs11568818, 12:114685571, rs11649743, rs7501939 and rs2735839.