Table 1 Variation attributable to different sources.

From: Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Source of variation

Developmental rate

Fertility

Genetic variation

83.1

63.3

 Among species

77.8*

50.9*

 Among strains w/in species

5.3*

12.4*

Reproducibility among labs

8.3

7.9

 Among labs

0.0

1.4

 Lab × species

4.2*

0.0

 Lab × strain

4.1*

6.5*

Reproducibility within labs

3.8

5.6

 Among trials w/in lab

3.8*

5.6*

Individual variation

4.8

23.3

Total

100

100

 Total number of observations

1,887

1,667

  1. Variation attributable to different sources within the hierarchical analysis of reproducibility within and among labs, species and strains in the absence of any chemical interventions for developmental rate and fertility. Each entry represents the percentage of the total trait variance explained by that particular factor as estimated by a general linear model. Larger values mean more variability attributable to that source, whereas lower values imply more consistent results across that source. Bold entries indicate a summation of the component numbers immediately beneath it.
  2. *95% Confidence interval bounded from zero in the maximum likelihood procedure (see Supplementary Table 1).
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