Figure 6: Deficits in GSIS in β-barr2 KO islets are rescued by a constitutively active CAMKII mutant (CA-CAMKII). | Nature Communications

Figure 6: Deficits in GSIS in β-barr2 KO islets are rescued by a constitutively active CAMKII mutant (CA-CAMKII).

From: β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Figure 6

Islets prepared from β-barr2 KO mice or control littermates were infected with adenoviruses coding for CA-CAMKII or GFP (control). After pre-incubation of islets with insulin secretion buffer for 30 min, islets were incubated in low or high-glucose buffer (2.8 or 28 mM glucose, respectively) for 1 h. Data are given as means±s.e.m. (n=4–8). **P<0.01, as compared with the indicated control group (two-way ANOVA followed by Student's t-test). ANOVA, analysis of variance.

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