Figure 7: Hypothetical models for PANX1 channel activation.
From: A quantized mechanism for activation of pannexin channels
(a) Schematics illustrate that individual cleavage at the C terminus of PANX1 subunits gradually increase unitary conductance (γ) and open probability (Po). (b) Post-translational modification (yellow star) of α1DR-activated PANX1 subunits gradually increases unitary conductance and open probability by either facilitating displacement of PANX1 C termini (left) or allosterically modulating channel gating via the displaced PANX1 C terminus (right).
