Figure 2: Examples of protein levels that are determined by multiple independent genetic variants.
From: Connecting genetic risk to disease end points through the human blood plasma proteome
Box-whisker plots of protein levels of (a) Haemopexin HPX and (b) SLAMF7 as a function of genotype. Data presented from the KORA study (N=997). Whiskers extend to the most extreme data point that still falls within the 1.5 inter-quartile range. The number of minor alleles of the respective genetic variant is given; for instance, in a, ‘002’ refers to individuals that are homozygous for the major alleles of rs61818956 and rs4915318 and for the minor allele of rs10494745, and in b, ‘0.2’ refers to homozygotes of the major allele of rs11581248 and the minor allele of rs489286. Only variant combinations that were observed in the study population are shown in the case of HPX. SNPs rs61818956, rs4915318 and rs10494745 are located in trans in the CFHR2/CFHR4 gene locus. Further examples are shown in Supplementary Fig. 2.
