Figure 2: FAK is required for adipocyte survival.

(a,b) Body weight in male (a) and female (b) littermate control or aP2FAK^−/− mice fed chow diet (n=10). (c,d) Representative haematoxylin and eosin (H&E) and TUNEL of perigonadal WAT sections from 4- to 6-week-old mice (n=3 mice) (c) and 20-week-old mice (n=4 mice) (d) (black scale bar, 100 μm; white scale bar, 100 μm, arrows indicate positive nuclei). (e,f) Body composition expressed as per cent total body weight in 4- to 6-week- (n=5) (e) and 20-week-old (f) male (blue) and female (red) mice (n=6 males, 5 females). (g–i) Adipocyte size distribution (g), average adipocyte diameter (h) and calculated total adipocyte number (i) in 20-week-old mice (n=4 mice). Data are mean±s.e.m. *P<0.05 by Student’s t-test between means.