Figure 3: A subset of enhancer-associated insertions is predicted to alter enhancer activity.
From: Small genomic insertions form enhancers that misregulate oncogenes
(a) Cartoon depicting two plausible models of the effect of insertions on enhancers. If insertions do affect enhancers, there should be more ChIP-Seq reads for enhancer-binding proteins that contain the insertion than do not. (b) Counts of predicted enhancer-associated insertions in all tested samples that bias ChIP-Seq read mapping and thus are likely associated with altered enhancer activity. (c–e) Example enhancer-associated insertions that are predicted to alter enhancer activity. Counts of ChIP-Seq reads for H3K27ac are displayed in purple. RefSeq gene positions are noted below. ChIP-Seq reads containing the predicted insertion are noted below. The insertion is noted in red.
