Figure 6: Determination of the stoichiometry of BV binding to Syn BVR.

(a) BV titration of Syn BVR (10 μM), as determined from the difference absorption spectra acquired in the presence of NADP+. Arrows indicate trends of spectral changes. (b) Titration curve of Syn BVR observed at 740 nm. (c) Titration curve of the Syn BVR R185A mutant. Measurements were performed in triplicate.