Figure 4: Recurrent gained VELs in adenomas.
From: Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
(a) Per cent of gained VELs identified in primary adenoma samples at each recurrence. (b) Scatter plot comparing H3K27ac ChIP-seq signals at G30+ VELs in adenomas (x axis) versus CRC cell lines (y axis) relative to normal colon crypt. The linear regression line for each set of enhancers is shown (dotted lines). (c) Normalized H3K27ac ChIP-seq tracks for two adenomas compared with CRC and normal colon H3K27ac super-tracks (median binned signal of all normal crypts or all CRC cell lines) at four loci representative of recurrent gained VELs in the CRC cell lines that are absent (left) and present (right) in adenomas.
