Figure 1: The I. scapularis XIAP interactome.
From: Infection-derived lipids elicit an immune deficiency circuit in arthropods
Top 50 related genes interacting with the human (a) XIAP and (b) ML-IAP were compiled in a network according to GeneMANIA. Interactomes were visualized by using Cytoscape. Networks and biological pathways were integrated based on previously observed protein and genetic interactions, pathway, and co-localization assays. Proteins were grouped according to the GO functional categories available at DAVID. Size corresponds to the score given to each node. Edge type is based on the interaction map. Width is determined by scored evidence of interaction. (c) I. scapularis homologues were obtained with PSI-BLAST and GeneCard searches based on the human XIAP or the ML-IAP interactome. Sixty-eight candidates were grouped according to the GO functional categories available at DAVID. Immunity genes are represented in green and all candidates highlighted in red are predicted to be involved in the arthropod IMD pathway. See also Supplementary Figs 1–4 and Supplementary Table 1.
