Figure 3: Synthesis of 2nd generation sansanmycin analogues 21–37 with inhibitory activities against Mtb H37Rv.

MIC₅₀ values represent average of two independent experiments, each performed in triplicate; positive controls RIF: MIC₅₀=0.006±0.002 μM; INH: MIC₅₀=0.025±0.005 μM; MIC₅₀ (HEK293) for 21–37>200 μM.