Figure 9: Schematic illustrating the emergence and subsequent pattern of contribution of Foxa2-vCPs during cardiac development.
From: Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential
Foxa2-vCPs (indicated in green) emerge during gastrulation (E6.5–7.5). Progeny derived from the Foxa2-vCPs (continued in green) start expressing the CM markers Pdgfra and Kdr, and migrate to the anterior side of the embryo. In the CC, Foxa2-vCP progeny contribute to both the FHF and SHF, and are located primarily at the apex of the crescent. Finally, in the differentiated four-chambered heart, Foxa2-vCP progeny give rise to cardiomyocytes, endothelial cells and conduction system cells of the left and right ventricular chambers, and to epicardial cells of the entire heart.
