Figure 7: Mutant Kras and inactivated p16 orchestrate metabolic reprogramming in PDAC.

The proposed working model of the function and mechanisms of NOX4 in reprogramming aerobic glycolysis initiated by activated Kras and inactivated p16 in PDAC.
The proposed working model of the function and mechanisms of NOX4 in reprogramming aerobic glycolysis initiated by activated Kras and inactivated p16 in PDAC.