Figure 2: miRNA profile from exosomes is different from their donor cells.
From: MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression
(a) Comparative analysis of the miRNome in exosomes and exosome donor tissues using a microarray. miRNAs from exosomes and exosome donor tissues, including primary colon cancer (top panel) and liver metastasis (middle panel), were quantitatively analysed and expressed as a ratio of miRNAs from exosome donor tissues/exosomes. The similarity of each individual miRNA distribution in primary colon cancer and liver metastasis was analysed by overlaying each and are shown in yellow (bottom panel). Expression of miR-193a (b), miR-18a (c) and miR-21 (d) in the exosomes and exosome donor tissues, including primary colon cancer and liver metastasis of colon cancer, were assessed by qPCR. *P<0.05 (two-tailed t-test). Data are representative of three independent experiments (error bars, s.e.m.).
