Figure 1: Conditional deletion of the Ant2 gene in the murine liver.
From: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
(a) Schematic diagram of liver-specific Ant2 gene disruption strategy. (b) Immunoblot analysis for Ant1, Ant2 and TOM20 expression in mitochondrial lysates isolated from liver (L), skeletal muscle (SK) and kidney (K) of control (Alb/Cre−;Ant2fl/Y) and cKO (Alb/Cre+;Ant2fl/Y) mice. (c) Representative phenotypes of control and cKO mice (20 weeks old). (d) Body weight of 6- to 35-week-old mice (*P<0.05, **P<0.01, ***P<0.001). (e) TD-NMR analysis of fat mass in 16 weeks old mice (n=12; *P<0.05 by t-test, error bars=s.d.).
