Figure 5: Ant2 deletion in the liver mitigates obesity under a high fat diet.
From: Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Control and Ant2 cKO mice at the age of 28 weeks were subjected to a high fat diet (60%) for 4 weeks. (a) Body weight changes under the high fat diet regimen (n>9, *P<0.05, **P<0.01 by t-test, error bars=s.d.). (b) Fat and lean mass assessed by TD-NMR analysis (n=10, **P<0.01 by t-test, error bars=s.d.). (c) Weight of white adipose tissue (n=10, ***P<0.001 by t-test, error bars=s.d.). (d) Energy expenditure assessed by a comprehensive laboratory animal monitoring system (CLAMS). (e) Plasma levels of fasting glucose and HbA1c (n=10, ***P<0.001 by t-test, error bars=s.d.). (f) Glucose infusion rate during hyperinsulinemic-euglycemic clamp (n=5, *P<0.05 by t-test, error bars=s.d.).
