Figure 5: Working hypothesis for the mode of action and optimization of R. | Nature Communications

Figure 5: Working hypothesis for the mode of action and optimization of R.

From: Arylmethylamino steroids as antiparasitic agents

Figure 5

(a) Ortho-hydroxylated arylmethyl amines exhibit the highest antimalarial activity. A chelate involving quinone methide mechanism is substantiated via structure/activity considerations. Both the redox pair phenol/quinone and the highly reactive quinone methide itself may be causative for biological activity. (b,c) The steroid core also plays a crucial role. The highest activity is found for estratriene derivatives.

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