Figure 2: Cx3cr1-deficient mice exhibit a female-specific obesity phenotype.
From: Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice
(a–d) Body-weight gain (a,b) and cumulative food intake (c,d) measured in Cx3cr1-HT and KO mice on chow and HFD for 18 weeks (a,c: males; b,d: females). (e–h) Total fat mass (e,f) and lean mass (g,h) measured at study end in HT and KO mice (e,g: males; f,h: females). (i–k) Average adjusted heat production during 12h light cycle (i), 12h dark cycle (j) and both photoperiods combined (total) (k) in HT and KO female mice exposed to HFD for 18 weeks. Heat production was adjusted using normalization to lean mass+0.2 × fat mass (see ‘Methods’ section). (l,m) Intraperitoneal glucose tolerance test (2 g kg−1) in HT and KO mice on chow and HFD for 18 weeks (l: males; m: females). (n,o) Glucose AUC analysis of data from (l,m), respectively. Data are presented as mean±s.e.m. of 12 males and 8 females per group for all panels except (i–k) where n=8 females per group. For all panels, data are analysed by repeated measures or two-way ANOVA followed by Bonferroni post hoc comparisons. *P<0.05, **P<0.01 and ***P<0.001 versus chow groups; #P<0.05, ##P<0.01, ###P<0.001 HT-HFD compared to HT chow. †P<0.05 and †††P<0.001 KO-HFD versus HT-HFD.
