Figure 1: Spatial sampling and genomic profiles.

(a) A schematic flow of our sectoring design. A central slice was cut from the patient tumour. A linear grid of tumour sectors was then harvested. (b) Oncoprint plot for 18 HCC drivers across 9 patients. Mutation rates, tumour purity and mutation presence data are shown in the top, middle and bottom panels. The mutation frequencies of each HCC driver gene (left side bar) were extracted from a large collection of public data sets (Methods). Sectors from each patient are ordered from left to right according to their names (T1 being the most left sector). Red shows the mutations whose frequencies are >15% and blues are those with frequencies <15%. For patient 3, we have no information for TERT promoter mutations due to exome sequencing. (c) Copy number profiles at GISTIC cytobands. Each cytoband is one row and chromosomal arms of the cytobands are shown on the right. The number in the parentheses is the total number of cytobands in that chromosome arm. Precise cytoband IDs are listed in Supplementary Fig. 4. Left side bar is the copy number profile in the GISTIC analysis. Red designates amplifications and blue is for deletions. (d) Copy number profiles of potential driver genes. Format is as c.