Figure 5: NEKO mice have a defect in response to dehydration and vasopressin.
From: Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
(a–c) Blood sodium (a), potassium (b) and chloride (c) in control and NEKO mice at 8–12 weeks of age after 24 h of water deprivation. Data are the means±s.e. (n=4) (**P<0.01, unpaired t-test). (d) Urine osmolality of NEKO mice at 8–12 weeks of age after 24 h of water deprivation. (**P<0.01, unpaired t-test) (e) dDAVP stimulation test of control and NEKO mice at 8–12 weeks of age after water loading. Mice were given water containing 5% sucrose before the experiment to ensure production of dilute urine. Urine was collected and 1 ng g−1 body weight of dDAVP was i.p. injected. Urine osmolality was measured at 1 and 2 h after the injection. (**P<0.01, unpaired t-test).
