Figure 6: Deletion of renal tubular Keap1 from embryonic stage but not from adult stage leads to polyuria.
From: Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus
(a,b) Control and Keap1-TKO mice were treated with DOX from adult stage. Urine volume (a) and relative transcript levels of Keap1 and Nqo1 genes in the kidney (b) of the mice are shown. (c–f) Control and Keap1-TKO mice were treated with DOX from embryonic stage. Urine volume (c), relative transcript levels of Keap1 and Nqo1 genes in the kidney (d), urine osmolality (e) and volume of drinking water consumed (f) by the mice are shown. Data of gene expression are the means±s.e. (n=8). (*P<0.05. **P<0.01, unpaired t-test).
