Figure 1: Excessive thickness of Fat4 mutant hearts.
From: Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth
Whole mount views (a) and histological sections (b) of Fat4+/− and Fat4−/− neonatal (P0) hearts. The arrowhead points to the flattened apex and double arrows highlight ventricular wall and septum thickness. (c) Quantification of the thickening in Fat4+/+ (n=7), Fat4+/− (n=5) and Fat4−/− (n=6) hearts. ***P<0.001 (analysis of variance). Scale bar: 500 μm. RV, right ventricle; LV, left ventricle. In all figures, data are presented as means±standard deviations, normalized to the level of control hearts when appropriate.
