Figure 4: Ovarian explant cultures supported follicle development and hormone secretion in the Solo-MFP and Duet-MFP.
From: A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
(a,b) Concentrations of pituitary hormones, FSH and hCG, in the acceptor module during 28-day microfluidic culture. (c) Ovarian explants were cultured in the Solo-MFP and Duet-MFP, in which follicles developed from the pre-antral to antral stage, and extruded MII oocytes following hCG stimulation. (d,e) Secretion of oestradiol (E2) and progesterone (P4) in the Solo-MFP and Duet-MFP. (f,g) Secretion of inhibin A and inhibin B in the Solo-MFP and Duet-MFP. Graphs in a,b,d–f display average+s.d. Scale bar, 50 μm. n=3–5 replicates for the Solo-MFP and Duet-MFP microfluidic cultures.
